Severe toxic hepatitis associated with amoxycillin and clavulanic acid
Articles > Article · 2001
Authors: Galip ERSÖZ, Abdullah Zeki KARASU, C. Yildiz, Ulus Salih AKARCA, G. Yuce, Y. Batur
Journal of Clinical Pharmacy and Therapeutics, International, WoS, 2001, vol 26, pp 225-229
DOI: 10.1046/j.1365-2710.2001.00341.x
Summary
Toxic hepatitis secondary to amoxycillin-clavulanic acid is an infrequent clinical picture. Most of the cases are reported to have a benign course. We report two cases of severe hepatic failure following amoxycillin-clavulanic acid use. One of the cases had cholestatic features primarily, and the other had hepatocellular injury prominently. The first case had also findings of trombotic trombositic purpura and had a fatal course.