Functional convergence of Akt protein with VEGFR-1 in human endothelial progenitor cells exposed to sera from patient with type 2 diabetes mellitus
Makaleler > Tam Makale · 2017
Yazarlar: Mehdi HASSANPOUR, Aysa REZABAKHSH, Reza RAHBARGHAZI, Alireza NOURAZARIAN, Mohammad NOURİ, Çığır BİRAY AVCI, Shahrooz GHADERİ, Neda ALİDADYANİ, BAKİYE GÖKER BAĞCA, Hesam Saghaei BAGHERİ
Microvascular Research, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2017, cilt 114, ss 101-113
DOI: 10.1016/j.mvr.2017.07.002
Özet
Diabetes mellitus type 2 predisposes patients to various microvascular complications. In the current experiment, the potent role of diabetes mellitus was investigated on the content of VEGFR-1,-2, Tie-1 and-2, and Akt in human endothelial progenitor cells. The gene expression profile of mTOR and Hedgehog signaling pathways were measured by PCR array. The possible crosstalk between RTKs, mTOR and Hedgehog signaling was also studied by bioinformatic analysis.