Investigation of biological activities and bioactive compounds of Rhynchostegium megapolitanum collected from Aydın, Türkiye
Makaleler > Tam Makale · 2026
Yazarlar: Birsen Kırım, Rukiye Yavaşer Boncooğlu, Mehran Aksel, Ali Özmen, Esin Poyrazoğlu, Safiye EMİRDAĞ, Hacı Halil Bıyık, A. Alev Karagözler, İlke Demirkaya, İlknur Babahan Bırcan
International Journal of Agriculture, Environment and Food Sciences, Uluslararası, 2026, ss 578-594
Özet
This study examines the antioxidant, antimicrobial, and anticancer properties of methanol, chloroform, and n-hexane extracts from Rhynchostegium megapolitanum, a moss species collected in Aydın, Türkiye. Total phenolic, flavonoid, and tannin contents were quantified. Antioxidant activity was evaluated using DPPH and ABTS assays, yielding 76.0%, 71.4% and 7.93% DPPH and 59.1%, 21.3% and 4.44% ABTS radical scavenging activities for methanol, chloroform and hexane extracts, respectively. Antimicrobial activity was tested against 17 bacteria and 4 yeasts, showing significant efficacy, particularly against Gram-positive bacteria. Methanol extracts of R. megapolitanum exhibited notable antibacterial effects. Anticancer activity was evaluated on PC-3 and MCF-7 cancer cell lines. Cytotoxicity was assessed using Hoechst/PI double staining, and paclitaxel (1 µM) served as a positive control. The extracts, in apoptosis mechanism demonstrated concentration-dependent antiproliferative effects (5–40 µM), supporting their potential as natural therapeutic agents in cancer research.