Yavaş Bilişsel Tempo ve Dikkat Eksikliği Hiperaktivite Bozukluğu: Benzerlikleri ve Farklılıkları
Makaleler > Tam Makale · 2020
Yazarlar: Gül Ünsel Bolat, Hilmi Bolat, Semiha ÖZGÜL, Serkan Süren, Kemal Utku Yazıcı, Ali Bacanlı, HASAN AKIN TAHILLIOĞLU, Erhan PARILTAY, Haluk AKIN, Eyüp Sabri ERCAN
Çocuk ve Gençlik Ruh Sağlığı Dergisi, Diğer Kurumların Hakemli Dergileri, Ulusal, Index Copernicus, 2020, cilt 27, ss 170-179
DOI: 10.4274/tjcamh.galenos.2020.65707
Özet
<p>Objective: Studies to reduce the heterogeneity of attention-deficit/hyperactivity disorder (ADHD) have</p><p>increased interest in the concept of sluggish cognitive tempo (SCT). The aim of this study was</p><p>to investigate if the prevalence of two variable-number tandem repeats (VNTRs) located within the</p><p>30-untranslated region of the DAT1 gene and in exon 3 of the dopamine D4 receptor (DRD4) gene</p><p>differ among four groups (31 subjects with SCT but no ADHD, 146 individuals with ADHD but no SCT,</p><p>67 subjects with SCT + ADHD, and 92 healthy controls).</p><p>Methods: We compared the sociodemographic profiles, neurocognitive domains, and prevalence of</p><p>two VNTRs in SCT and ADHD subjects versus typically developing (TD) controls.</p><p>Results: The SCT without ADHD group had a higher proportion of females and lower parental</p><p>educational attainment. Subjects in this group performed worse on neuropsychological tests, except</p><p>for psychomotor speed and commission errors, compared to controls. However, the ADHD without</p><p>SCT group performed significantly worse on all neuropsychological domains than controls. We found</p><p>that 4R homozygosity for the DRD4 gene was most prevalent in the ADHD without SCT group. The</p><p>SCT without ADHD group had the highest 7R allele frequency, differing significantly from the ADHD</p><p>without SCT group.</p><p>Conclusion: The 7R allele of DRD4 gene was found to be significantly more prevalent in SCT cases</p><p>than in ADHD cases. No substantial neuropsychological differences were found between SCT and</p><p>ADHD subjects.</p><p>Keywords: attention-deficit/hyperactivity disorder; sluggish cognitive tempo; dopamine transporter</p><p>gene; dopamine receptor D4 gene; psychomotor speed</p>