R132H Mutation in IDH1 Gene is Associated with Increased Tumor HIF1-Alpha and Serum VEGF Levels in Primary Glioblastoma Multiforme.
Makaleler > Tam Makale · 2017
Yazarlar: Cem Yalaza, Handan Ak, Mehmet Sedat Cagli, Erkin ÖZGİRAY, Sevcan Atay, Hikmet Hakan AYDIN
Annals of clinical and laboratory science, Uluslararası, 2017, cilt 47, ss 362-364
Özet
GOALS: have been identified in a number of cancers, their role in tumor development has not been fully elucidated. In this study, we aimed to investigate the association between IDH1 mutations, tumor tissue HIF-1 alpha, and serum VEGF levels in patients with primary GBM for the first time. METHODS: test for continuous variables. RESULTS: =0.0454, respectively). CONCLUSION: Our results suggest that mutated IDH1 may contribute to carcinogenesis via induction of HIF-1 alpha pathway in primary GBM.