Microalbumin excretion and outcome in children with multicystic dysplastic kidney
Makaleler > Tam Makale · 2012
Yazarlar: Ipek Akil, Nese Biyikli, Pınar YAZICI ÖZKAYA, Beyhan Cengiz Ozyurt, Harika Alpay
TURKISH JOURNAL OF MEDICAL SCIENCES, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2012, cilt 42, ss 1039-1043
Özet
Aim: To present the long-term follow-up results of children with multicystic dysplastic kidney (MCDK) and urinary microalbumin excretion levels in order to evaluate whether there is an increased risk of renal damage or not.Materials and methods: Thirty-three children with the diagnosis of MCDK who had been followed up by the nephrology outpatient clinic between 2002 and 2009 were invited to participate in the study. Twenty-six healthy children were investigated as a control group for microalbumin/creatinine ratio (mu g/g creatinine). The mean age at diagnosis, the duration of follow-up, accompanying urinary tract abnormalities, attacks of urinary tract infection (UTI), contralateral kidney size, and urinary microalbumin levels were investigated.Results: The mean age of the patients with MCDK and the mean duration of follow-up were 6.5 +/- 3.9 years and 35 months (range 2-96) months, respectively. The most common urinary tract abnormality was vesicoureteral reflux (VUR), with a rate of 34%. Thirty-nine percent of the children experienced UTI during follow-up. The compensatory renal hypertrophy of the contralateral kidney was 24% at 6 months and 68% at 12 months. Sixteen patients (59%) had an increased microalbumin/creatinine ratio (>30 mu g/mg creatinine). Microalbumin/creatinine ratio was higher in patients with MCDK than it was in the controls (P = 0.001).Conclusion: Microalbuminuria and VUR are not rare in children with MCDK. Systematic follow-up of these patients is recommended to identify those at risk of contralateral renal damage.