131I labeling of tamoxifen and biodistribution studies in rats
Makaleler > Tam Makale · 2007
Yazarlar: Fazilet Zümrüt BİBER MÜFTÜLER, P. Unak, S. Teksoz, Çiğdem İÇHEDEF, S. Yolcular, Y. Yurekli
Applied Radiation and Isotopes, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2007, cilt 66, ss 178-187
DOI: 10.1016/j.apradiso.2007.08.005
Özet
Tamoxifen [TAM ([Z]-2-[4-(1,2-diphenyl-1-di-butenyl)-phenoxy]-N,N-dimethylethanamine)] has been used as an antiestrogen drug for treatment and prevention of human breast cancer. Tamoxifen was labeled with I-131 using iodogen as an oxidizing agent. Mass spectroscopy of the cold standard showed that the labeling occurs in ortho position to the phenyl ether position of TAM as expected. Quality control, radiochemical yield and stability were established using the radioelectrophoresis method. The radiolabeled compound maintained its stability throughout working period of 24 h. Scintigraphic imaging was performed and tissue distribution was determined in Albino Wistar rats. According to biodistribution and imaging experiments the radiolabeled compound presented estrogen receptor (ER) specificity and it was uptaken by endometrium as well as breast tissue. (C) 2007 Elsevier Ltd. All rights reserved.