High degree of conservation in the hepatitis B virus core gene during the immune tolerant phase in perinatally acquired chronic hepatitis B virus infection
Articles > Article ยท 1997
Authors: H Bozkaya, Ulus Salih AKARCA, B Ayola, ASF Lok
JOURNAL OF HEPATOLOGY, Journal Indexed in SCI Expanded, International, 1997, vol 26, pp 508-516
DOI: 10.1016/s0168-8278(97)80415-1
Summary
Background: Mutations in the hepatitis B virus genome have been implicated in the persistence of hepatitis B virus infection and the pathogenesis of hepatitis B virus related liver disease, In view of the heterogeneity in published sequences, data from cross-sectional studies of unrelated subjects cannot differentiate true mutations from infections with variant sequences.