Increased expression of electron transport chain genes in uterine leiomyoma.
Makaleler > Tam Makale · 2014
Yazarlar: Akile Tuncal, Hikmet Hakan AYDIN, Niyazi Askar, Ali Burak Ozkaya, Ahmet Mete Ergenoglu, Ahmet Özgür YENİEL, Ali AKDEMİR, Handan Ak
Annals of clinical and laboratory science, Uluslararası, 2014, cilt 44, ss 466-8
Özet
The etiology and pathophysiology of uterine leiomyomas, benign smooth muscle tumors of the uterus, are not well understood. To evaluate the role of mitochondria in uterine leiomyoma, we compared electron transport gene expressions of uterine leiomyoma tissue with myometrium tissue in six uterine leiomyoma patients by RT-PCR array. Our results showed an average of 1.562 (±0.445) fold increase in nuclear-encoded electron transport genes. These results might suggest an increase in size, number, or activity of mitochondria in uterine leiomyoma that, to our knowledge, has not been previously reported.