PON192 Polymorphism and LDL-Oxidation As Risk Factors For Coronary Artery Disease in Young Turkish Population
Makaleler > Tam Makale · 2009
Yazarlar: Eser YILDIRIM SÖZMEN, Latife Meral KAYIKÇIOĞLU, Ebru SEZER, Bilal İLANBEY, Yasemin AKÇAY, Kadir Hakan KÜLTÜRSAY
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2009, cilt 34, ss 250-255
Özet
Purpose: There are conflicting reports on paraoxonase1 (PON1) polymorphism as a risk factor for cardiovascular disease. It's been proposed that there is relationship between coronary artery disease and PON1-55L or PON1-192R alleles. Nevertheless recent publications showed major differences of PON1 activity and concentration in different populations. We aimed to study low-density-lipoprotein (LDL) oxidation and PON1 activities (paraoxonase/arylesterase) regarding to PON192 polymorphism, in order to determine if they might be useful markers especially for young patients with coronary artery disease in Turkish population.