Self- and Observer-Rated Computer-Based Cognitive Function and Abilities Tests Are Valid for Dialysis Patients
Bildiriler > Özet Bildiri
Yazarlar: Krister Cromm, Özlem KUMAN TUNÇEL, Mirja Humpert, Le Hong Ngoc Pham, Tatiana De los Ríos, Yusuf Çelik, Ismail Agirbas, Tugce Bedel, Sibel Kaletas, Gülay AŞCI, Carrie R. Houts, RJ Wirth, Ercan OK, Hayriye ELBİ, DOPRO.
Journal of the American Society of Nephrology, , , Uluslararası, Özet Bildiri, Wos, cilt 34, ss 516-516
DOI: 10.1681/asn.20233411s1516d
Özet
Background: Cognitive Function and Abilities (CFA) are important factors in health-related quality of life (HRQOL) of dialysis patients and a prerequisite for performing hemodialysis (HD) at home. Congruence of self- and observer-reported CFA is debated for assessment in clinical trials. The purpose of the study was to support the use of a CFA measure in Turkish HD patients. Methods: We translated the 31-item PROMIS (Patient-Reported Outcomes Measurement Information System) CFA (PROMIS-CFA) subset according to FACIT methodology. PROMIS-CFA was filled in electronically by participants, Addenbrooke's Cognitive Examination-Revised (ACE-R) was assessed by psychologists at the same time during dialysis sessions. HRQOL was assessed with KDQOL-SF. Psychologist called participants on the next day for 16-item Telephone Cognitive Screen (T-Cog-S). Among 1164 patients treated in the 7 dialysis clinics, eligible patients were screened, and 151 in-center conventional HD and 26 home HD patients were randomly selected. Results: The final sample was composed of 63 females and 114 males with an average age of 55.5±13.4. The average time since kidney disease diagnosis was 10.4±8.2 years and the average time on dialysis was 74.4±66 months. Thirty-four patients had mild cognitive impairment based on categorized ACE-R scores. The internal consistency (Cronbach's α) for the PROMIS-CFA was .96 and the observed test-retest intraclass correlation coefficient over approximately 7 days was r=.70. There were significant but low correlations (r=.2-.28) between ACE-R and PROMIS-CFA scores, but higher correlations with HRQOL (r=.15-.44). T-Cog-S significantly correlated with ACE-R (r=.55), but not PROMIS-CFA. Conclusions: The Turkish translation of PROMIS-CFA is reliable and may support valid inferences regarding cognitive functioning and abilities in this population. Self-rated CFA is more closely related to HRQOL than observer-rated CFA. Future outcome studies should therefore include both assessments in larger samples. Telephone interviewing with T-Cog-S was not an alternative to clinical evaluation in detecting cognitive impairment due to high ceiling effects. Funding: Commercial Support - Fresenius Medical Care Deutschland GmbH