Tideglusib protects neural stem cells against NMDA receptor overactivation
Articles > Article · 2015
Authors: Güliz ARMAGAN, Ayşegül KESER, Çiğdem ATALAYIN ÖZKAYA, Taner DAĞCI
PHARMACOLOGICAL REPORTS, Journal Indexed in SCI Expanded, International, 2015, vol 67, pp 823-831
DOI: 10.1016/j.pharep.2015.01.007
Summary
Background: N-methyl-D-aspartate (NMDA) receptors are major pharmacological targets to prevent or reduce the progression of neurodegenerative diseases. Successful therapy with NMDA receptor antagonists in humans has been limited by the severe side effects of complete receptor blockade. The aim of the present study was to investigate the possible protective effects of tideglusib against NMDA receptor overactivation in neural stem cells.