Preventive effect of aminoguanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats
Makaleler > Tam Makale · 2009
Yazarlar: S. Atasayar, Hande GÜRER ORHAN, Hilmi ORHAN, B. Gurel, GÖZDE GİRGİN, H. Ozgunes
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2009, cilt 61, ss 23-32
DOI: 10.1016/j.etp.2008.04.016
Özet
In this study. the antioxidant effect of aminoguanidine on nephrotoxicity of a single dose of cisplatin is investigated and compared with the effects of well-known antioxidants vitamin C and E combination. Tubular damage and perivascular inflammation were observed in kidney samples of the cisplatin-administered groups. Aminoguanidine and vitamin C-E combination are found to be capable of preventing these effects of cisplatin. Liver tissues Of all groups were intact. Cisplatin-induced oxidative stress was evidenced by significant decrease in glutathione and significant increase in malondialdehyde levels in kidney samples. Antioxidants with cisplatin decreased malondialdehyde levels. Antioxidants with cisplatin prevented the decrease in liver glutathione levels. The nephrotoxicity was confirmed biochemically, by significant elevation of serum urea and creatinine levels. Both vitamin C-E combination and aminoguanidine prevented the increase in serum urea levels according to the cisplatin group. (C) 2008 Elsevier GmbH. All rights reserved.