Comparison of the efficacy and safety of long-acting anticholinergic and a combination of inhaled steroids and long-acting beta-2 agonist in moderate chronic obstructive pulmonary disease
Bildiriler > Özet Bildiri
Yazarlar: Pinar Sarac, Abdullah SAYINER
European Respiratory Journal, , , Uluslararası, Özet Bildiri, Wos, cilt 42, ss P4143-P4143
DOI: 10.1183/13993003/erj.42.suppl_57.p4143
Özet
Long-acting anticholinergics and inhaled steroid-long acting beta-agonist combinations are frequently prescribed in moderate COPD.We aimed to compare the efficacy and safety of these drugs in patients with moderate COPD.A total of 44 patients who presented to Ege University Chest Diseases out patient clinic and who were diagnosed with moderate COPD were included in the study.At the end of a two-week wash-out period,the patients were randomized to fluticasone-salmeterol combination or tiotropium.The demographic data of all the patients,frequency of exacerbations,post-bronchodilator spirometry and lung volumes,CAT(COPD Assessment Test)score,arterial blood gas analysis,BODE index and the six-minute walk distance were recorded in the third,sixth,ninth and twelfth month visits.The primary end point was defined as the rate of exacerbations.During the one-year follow-up period,the average number of exacerbations was1.2±1.7in Group1;2.2±2.1in Group 2(p = 0.070)and the number of severe exacerbations was0.6±1.0 in Group1;1.1±1.4in group 2(p=0.245).Statistically significant improvement was observed in both groups(p<0.05) in CAT scores and oxygen saturation values,these improvements were similar in the two groups.FEV1 levels increased by 44mL in the first group and by 99mL in the second group(p=0.707).Significant increases in PaO2 levels were obtained only in the first group(p=0.016).The six-minute walking distance tended to improve in the first group,but this did not reach statistical significance(p=0.084).Use of LAMA and ICS/LABA appear to have similar clinical effectiveness in moderate COPD patients.