Cycloartane glycosides from Astragalus plumosus var. krugianus and evaluation of their antioxidant potential
Articles > Article · 2013
Authors: Nilufer DENIZLI, Ibrahim HORO, Derya GÜLCEMAL, Milena MASULLO, Michela FESTA, Anna CAPASSO, Omer KOZ, Sonia PIACENTE, Özgen ALANKUŞ
Fitoterapia, Journal Indexed in SCI Expanded, International, WoS, 2013, vol 92, pp 211-218
DOI: 10.1016/j.fitote.2013.10.018
Summary
The methanol extracts of Astragalus plumosus var. krugianus Chamb. & Matthews afforded sixteen cycloartane glycosides among which krugianoside A, was never reported before. All compounds were evaluated for their cytotoxic activity in human skin fibroblast WS1 cells. For compounds exhibiting no significant effect on WS1 viability, the antioxidant potential was examined. Compounds 1 and 8 prevented elevation of ROS induced by t-BOOH, suggesting the potential activity of these compounds to protect fibroblasts from oxidative stress. (C) 2013 Elsevier B.V. All rights reserved.