Combining anti-cancer drugs with artificial sweeteners: Synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (tsac) complexes cis-[Pt(sac)(2)(NH3)(2)] and cis-[Pt(tsac)(2)(NH3)(2)]
Makaleler > Tam Makale · 2014
Yazarlar: Subhi A. Al-Jibori, Ghassan H. Al-Jibori, Lamaan J. Al-Hayaly, Christoph WAGNER, Harry SCHMİDT, Suna TİMUR, F. Baris Barlas, Elif Subasi, Shishir Ghosh, Graeme Hogarth
JOURNAL OF INORGANIC BIOCHEMISTRY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2014, cilt 141, ss 55-57
DOI: 10.1016/j.jinorgbio.2014.07.017
Özet
The new platinum(II) complexes cis-[Pt(sac)(2)(NH3)(2)] (sac = saccharinate) and cis-[Pt(tsac)(2)(NH3)(2)] (tsac = thiosaccharinate) have been prepared, the X-ray crystal structure of cis-[Pt(sac)(2)(NH3)(2)]center dot H2O reveals that both saccharinate anions are N-bound in a cis-arrangement being inequivalent in both the solid-state and in solution at room temperature. Preliminary anti-cancer activity has been assessed against A549 human alveolar type-II like cell lines with the thiosaccharinate complex showing good activity. (C) 2014 Elsevier Inc. All rights reserved.