Preparation and bioevaluation of Tc-99m-carbonyl complex of guanine
Articles > Article · 2011
Authors: Çiğdem İÇHEDEF, Serap TEKSÖZ, Kamile SENOCAK, Eser UCAR, Ayfer YURT KILÇAR
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, Journal Indexed in SCI Expanded, International, 2011, vol 289, pp 845-849
DOI: 10.1007/s10967-011-1164-1
Summary
The aim of this study is to prepare radiolabeled guanine with Tc-99m(CO) (3) (+) core. For this purpose, guanine has been radiolabeled with Tc-99m(CO) (3) (+) core. Quality control study of radiolabeled guanine molecule with Tc-99m(CO) (3) (+) core was performed by thin layer radio chromatography (TLRC) and high performance liquid radio chromatography (HPLRC). The results showed that the radiolabeling yield was quite high (94 +/- A 3%). Beside that Tc-99m(CO)(3)-Gua complex has showed good in vitro stability during the 24 h period. Radiopharmaceutical potential of this complex was evaluated in Wistar Albino Rats. It was concluded that Tc-99m(CO)(3)-Gua could be used as a nucleotide radiopharmaceutical for in vivo applications.