Magnesium reduces calcification in bovine vascular smooth muscle cells in a dose-dependent manner
Articles > Article · 2011
Authors: Fatih KIRCELLI, Mirjam E. PETER, Ebru Sevinc OK, Fatma Gül KOZCU, Mümtaz YILMAZ, Sonja STEPPAN, Gülay AŞCI, Ercan OK, Jutta PASSLICK-DEETJEN
NEPHROLOGY DIALYSIS TRANSPLANTATION, Journal Indexed in SCI Expanded, International, 2011, vol 27, pp 514-521
DOI: 10.1093/ndt/gfr321
Summary
Vascular calcification (VC), mainly due to elevated phosphate levels, is one major problem in patients suffering from chronic kidney disease. In clinical studies, an inverse relationship between serum magnesium and VC has been reported. However, there is only few information about the influence of magnesium on calcification on a cellular level available. Therefore, we investigated the effect of magnesium on calcification induced by beta-glycerophosphate (BGP) in bovine vascular smooth muscle cells (BVSMCs).