OSA and cancer in Europe: the European Sleep Apnea Database (ESADA) experience
Bildiriler > Özet Bildiri · 2017
Yazarlar: Athanasia Pataka, Ulla Anttalainen, Sofia Schiza, Izolthi Bouloukaki, Paschalis Steiropoulos, Brian Kent, Richard Staats, Pavol Joppa, Renata Riha, Maria Bonsignore, Pawel Sliwinski, Johan Verbraecken, Özen KAÇMAZ BAŞOĞLU, Carolina Lombardi, Zoran Dogas, Jan Hedner
Sleep and Control of Breathing, İtalya, Uluslararası, Sözlü Sunum, Özet Bildiri, 2017-2017, Wos, cilt 50, ss OA3209-OA3209
DOI: 10.1183/1393003.congress-2017.oa3209
Özet
Background: Experimental and clinical studies suggest a relationship between Obstructive Sleep Apnea (OSA) and cancer development or progression Objectives: To explore the association between the severity of OSA and prevalence of cancer among patients reported to the European Sleep Apnea Database (ESADA) after control of several known risk factors for cancer development Methods: A prospective multicentre cohort study of adult patients with OSA (Apnea/Hypopnea Index, AHI≥5). OSA severity was classified according to AHI, Oxygen Desaturation Index (ODI) and % night-time spent with oxygen saturation <90%(TSat90). A cross-sectional association between OSA and cancer prevalence was assessed at the time of the baseline visit in the database using logistic regression analysis. Results: Of 19,556 participants, 357 (1.8%, 59.4% male) had been diagnosed with malignancy. Patients with malignancy were older (p<0,001), had lower body mass index (BMI) (p=0.004) and neck circumference (p=0.001). AHI, ODI, TSat90, Epworth Sleepiness Scale (ESS), Subjective sleep length and latency did not differ between patients with/without malignancy. Total Sleep Time (p=0.02) was lower in patients with malignancy. In a multivariable regression analysis, the severity of OSA assessed by AHI or ODI was not significantly associated with cancer prevalence after adjustment for age, sex, BMI, smoking status and alcohol intake. However, in patients aged<50 years AHI≥5 was associated with increased risk of cancer (OR=2.47, 95%CI1.13- 5,44, p=0.024). Conclusion: In the large multicentric ESADA cohort there was an association between OSA (AHI cutoff 5) and a prevalent cancer diagnosis but only in patients aged below 50 years.