Study on labeling conditions of125I-synkavit by the iodogen method
Articles > Article · 1994
Authors: DURMUŞ ÖZDEMİR, Perihan ÜNAK
Journal of Radioanalytical and Nuclear Chemistry Letters, Journal Indexed in SCI Expanded, International, 1994, vol 187, pp 277-283
DOI: 10.1007/bf02166555
Summary
Labeling conditions of synkavit (2-methyl-1,4-naphthoquinol disodium phosphate) with iodine-125 have been studied. In this study, labeling temperature, reaction time, successive using of iodogen coated tubes, iodogen amount and synkavit concentrations have been determined to get optimum conditions for maximum labeling. Final results showed that when the labeling temperature, reaction time, synkavit concentration, and iodogen amount were, at room temperature, 15 min (in the case of successive using of three iodogen coated tubes), 2 mg ml-1 and 5 mg, respectively; labeling yield was 90% and specific activities of the order of 555 GBq mmol-1 (15 Ci mmol-1) have been obtained.