An alternative evaluation method for swelling studies of bioadhesive tablet formulations
Articles > Article · 2004
Authors: ESRA BALOĞLU, Hüseyin Ata KARAVANA, Sinem Yaprak KARAVANA
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, Journal Indexed in SCI Expanded, International, 2004, vol 9, pp 233-237
Summary
A new and alternative evaluation method is preferred for swelling studies of bioadhesive tablet formulations. CIELAB color coordinates, related to visual color response, are used for the first time to follow the swelling state and to calculate the swelling volume. The results are evaluated statistically. A simple equation is given to explain the relation between the swelling volume change % and color difference for three different bioadhesive formulations. It was found that the estimated equation is in good agreement with observed swelling volume results.