The effects of PPAR-γ agonist pioglitazone on renal ischemia/reperfusion injury in rats
Makaleler > Tam Makale · 2012
Yazarlar: Buket REEL, Mehmet Guzeloglu, Alper Bagriyanik, Soner Atmaca, Koray Aykut, Gokhan Albayrak, Eyup Hazan
Journal of Surgical Research, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2012, cilt 182, ss 176-184
DOI: 10.1016/j.jss.2012.08.020
Özet
Background: Acute renal failure due to renal ischemia/reperfusion (IR) injury is a significant clinical problem in cardiovascular surgery. Reactive oxygen species and inflammation play essential roles in the pathophysiology of IR injury. Matrix metalloproteinases (MMPs) are enzymes that play important roles in inflammation and mediate extracellular matrix degradation. It is known that peroxisome proliferatoreactivated receptor-gamma agonists have antiinflammatory and antioxidant effects. In the present study, we aimed to investigate the effects of pioglitazone, a synthetic peroxisome proliferatoreactivated receptor-gamma agonist, on MMPs and oxidative stress in a renal IR injury model in rats.