Evaluation of PTX/Mo 2 CTx-MXene@Fuc surface-engineered nanosheets in targeted combination therapy for triple-negative breast cancer
Makaleler > Tam Makale · 2025
Yazarlar: Derya Özel, Ayça Tunçel, Gül Kaya, Buse Sert, Selin Güleç, Ersan Harputlu, Cumhur Gökhan Unlu, Kasim Ocakoglu, Fatma YURT
Nanomedicine, Uluslararası, Wos, 2025, cilt 21, ss 195-211
DOI: 10.1080/17435889.2025.2595120
Özet
AIMS: CTx-MXene@Fuc combinations, emphasizing their performance in drug loading, release kinetics, oxidative stress induction, apoptosis, cell migration, and angiogenesis inhibition in cancer therapy. METHODS/MATERIALS: cytotoxicity, ROS generation, apoptosis, migration, and tube-formation assays were performed on cancer (4T1, MDA-MB-231) and normal (L929) cell lines under NIR (808 nm) irradiation. RESULTS: The nanosheets exhibited high PTX loading efficiency (85-90%) and pH-sensitive drug release, with accelerated release in acidic tumor-mimicking environments. NIR irradiation significantly enhanced ROS production in cancer cells while maintaining low oxidative activity in normal cells. Apoptosis assays confirmed pronounced cell death under NIR+ conditions, while migration and tube-formation analyses revealed that MXene nanosheets moderately inhibited cell motility and suppressed endothelial angiogenesis. These results demonstrated synergistic enhancement of photothermal, photodynamic, and chemotherapeutic effects. CONCLUSION: CTx-MXene@Fuc nanosheets function as a multifunctional nanoplatform combining chemo-, photothermal-, and photodynamic-therapy mechanisms. Their selective cytotoxicity, ROS-mediated apoptosis, and anti-angiogenic activity highlight their strong potential for future targeted cancer therapy applications.