Relationship between Viral Load and Hepatic Histopathology in Patients with Chronic Hepatitis B
Makaleler > Tam Makale · 2020
Yazarlar: Damla VERENDAĞ, Tansu YAMAZHAN, Hüsnü PULLUKÇU, Meltem TAŞBAKAN, İsabel Raika DURUSOY
Viral Hepatitis Journal, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2020, cilt 26, ss 1-4
DOI: 10.4274/vhd.galenos.2019.2019.0040
Özet
Objectives: It is not always possible to determine a clear relationship between the DNA level of hepatitis B virus (HBV) and histology.In this study, we aimed to determine the relationship between HBV-DNA level and liver histopathology in patients with chronic hepatitis.Materials and Methods: Between 2008 and 2016, 361 patients diagnosed with chronic HBV infection were retrospectively examined with age, sex, hepatitis B e antigen status, alanine aminotransferase (ALT) and HBV-DNA levels and liver biopsy scores according to modified Ishak criteria.Patients were divided into five groups (10 5 , 10 5 -10 6 , 10 6 -10 7 , 10 7 -10 8 , ≥10 8 ) based on their HBV-DNA level (IU/mL) and upon histopathological evaluation, hepatic injury was divided into two groups -mild and moderate/severe-according to Ishak score (grade 1-6: mild, 7-18: moderate/severe and stage 0-2: mild, 3-6: moderate/severe) to investigate the statistical relationship between HBV-DNA levels and grade/stage scores.Cross-table and Pearson's chi-square test were used in the analyses.Results: Of the three hundred and sixty-one patients, 62.3% (225/361) were male and the average age was 40.32±12.79.Anti-HBe (296/361) was positive in 82% of the patients, ALT, HBV-DNA averages were 83.17 U/L (±125.1),57298951.01IU/mL during biopsy, and grade and stage averages were 5.34 and 1.76 respectively.HBV-DNA groups with the grade's 2-binary groups when compared to moderate/high group, respectively, HBV-DNA <10 5 and 17.2%, 10 5 -10 6 37%, 10 6 -10 7 % in 46.9, 107-10 8 % and 48.6 and 35.1 in ≥108 were found.The difference between the groups was found to be statistically significant (p<0.000).Similarly, HBV-DNA groups when compared to stage-binary groups, in the middle/high group, respectively, HBV-DNA 17.2% in <105, 32.6% in 10 5 -10 6 , 51% in 10 6 -10 7 , 48.6% in 10 7 -10 8 and 35.1% in ≥10 8 group were found and all of them were statistically significant (p<0.000).Conclusion: A HBV-DNA level was not found to be a threshold determining moderate/severe histopathological level.However, in group analysis, the histopathological relationship with the DNA level is directly proportional.Liver histology is an important marker determining the progression of the disease.Keywords: Viral hepatitis,