Is mannitol effective against platelet-activating factor (PAF)-induced liver damage in obstructive jaundice?
Makaleler > Tam Makale · 2001
Yazarlar: AHMET ÇOKER, IŞIL ÇOKER, Afig BERDELİ, S SOKMEN, S KARADEMİR
HEPATO-GASTROENTEROLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2001, cilt 48, ss 1134-1137
Özet
Background/Aims: Platelet-activating factor, is a unique phospholipid with a broad range of biological activities that may be relevant in the development of inflammatory reactions. Platelet-activating factor has been suspected to play an important role in liver pathophysiology. The cultured Kupffer and endothelial cells produce and release platelet-activating factor in order to facilitate communication between hepatic sinusoidal and parenchymal cells. In this study, in the experimental jaundice model, platelet-activating factor levels were measured in liver tissue and plasma and the possible effects of mannitol on this mediator were assessed.