Multi-institutional analysis of cervical esophageal carcinoma patients treated with definitive chemoradiotherapy: TROD 01-005 study
Makaleler > Tam Makale · 2023
Yazarlar: Ozan Cem Güler, EZGI OYMAK, Gözde Yazıcı, Özlem ÖZKAYA AKAGÜNDÜZ, OGUZ CETINAYAK, Özge Petek Erpolat, Rahmi Atıl Aksoy
ONCOLOGY RESEARCH, SCI Expanded İndekslerine Giren Dergi, Uluslararası, PubMed, 2023, cilt 31, ss 299-306
DOI: 10.32604
Özet
<p>Abstract: The aim of this study was to examine the prognostic factors and treatment outcomes of cervical esophageal</p><p>carcinoma (CEC) patients who underwent definitive chemoradiotherapy (CRT). The clinical data of 175 biopsyconfirmed</p><p>CEC patients treated with definitive CRT between April 2005 and September 2021 were retrospectively</p><p>analyzed. The prognostic factors predicting overall survival (OS), progression-free survival (PFS), and local</p><p>recurrence-free survival (LRFS) were assessed in uni- and multivariable analyses. The median age of the entire cohort</p><p>was 56 years (range: 26–87 years). All patients received definitive radiotherapy with a median total dose of 60 Gy, and</p><p>52% of the patients received cisplatin-based concurrent chemotherapy. The 2-year OS, PFS, and LRFS rates were</p><p>58.8%, 46.9%, and 52.4%, respectively, with a median follow-up duration of 41.6 months. Patients’ performance</p><p>status, clinical nodal stage, tumor size, and treatment response were significant prognostic factors for OS, PFS, and</p><p>LRFS in univariate analysis. Non-complete treatment response was an independent predictor for poor OS (HR = 4.41,</p><p>95% CI, 2.78–7.00, p < 0.001) and PFS (HR = 4.28, 95% CI, 2.79–6.58, p < 0.001), whereas poor performance score</p><p>was a predictor for worse LRFS (HR = 1.83, 95% CI, 1.12–2.98, p = 0.02) in multivariable analysis. Fifty-two patients</p><p>(29.7%) experienced grade II or higher toxicity. In this multicenter study, we demonstrated that definitive CRT is a</p><p>safe and effective treatment for patients with CEC. Higher radiation doses were found to have no effect on treatment</p><p>outcomes, but a better response to treatment and a better patient performance status did.</p>