Alterations in Retinal Vascularity in Severe Psoriasis.
Articles > Article · 2023
Authors: Mine ESEN BARIŞ, İdil ÜNAL, Suzan GÜVEN
OCULAR IMMUNOLOGY AND INFLAMMATION, Journal Indexed in SCI Expanded, International, Pubmed, 2023, vol 32, pp 1-5
DOI: 10.1080/09273948.2023.2166536
Summary
Purpose To evaluate the changes in retinal vascularity in patients with severe psoriasis.Materials and Methods Patients with severe psoriasis [psoriasis area-severity index (PASI) >10] who did not get any systemic treatment in the last year and do not have any ocular diseases were included. All patients underwent detailed ophthalmological examination, including optical coherence tomography (OCT) and OCT angiography (OCTA). Vessel densities (VD) of Superficial (SCP) and deep (DCP) capillary plexus, foveal avascular zone (FAZ) diameter, central retinal thickness (CRT) were analyzed and compared with age-sex matched healthy adults.Results Fifty-three patients (13 F, 40 M) and 56 controls (16 F, 40 M) were included in the study. VD of SCP (50.4%±3.9 vs. 51.4%±3.2) and DCP (52.6%±6.4 vs. 55.4%±5.7) were lower in psoriasis group compared to controls (p < .05). Presence of psoriatic arthritis was related with an increased CRT (p = .000), larger FAZ and decreased foveal VD in SCP (p = .01, p = .02, respectively).Conclusion Severe psoriasis causes a decrease in retinal blood flow and presence of psoriatic arthritis is related with decreased foveal VD.