Investigation of galectin-3 and heparanase in endometrioid and serous carcinomas of the endometrium and correlation with known predictors of survival
Articles > Article · 2010
Authors: çiğdem EGE, METİN AKBULUT, Osman ZEKİOĞLU, Necmettin ÖZDEMİR
ARCHIVES OF GYNECOLOGY AND OBSTETRICS, Journal Indexed in SCI Expanded, International, 2010, vol 284, pp 1231-1239
DOI: 10.1007/s00404-010-1766-9
Summary
Inhibitors of tumor angiogenesis and metastasis are emerging as important new drug candidates for cancer therapy. Galectin-3 and heparanase have been shown to function in tumor progression and metastatic spread. Both of them exert pleiotropic effects; proliferation, cell migration, differentiation and tissue remodeling. The aim of this study was to investigate heparanase and galectin-3 expression in endometrioid and serous carcinomas of the endometrium and their relation with well-known prognostic factors, in addition to estrogen, progesterone, C-erbB-2, Ki-67 and p53.