Determination of serum bile acids routinely may prevent delay in diagnosis of total parenteral nutrition-induced cholestasis
Articles > Article · 1999
Authors: M DEMIRCAN, Mustafa Orkan ERGÜN, S AVANOGLU, Funda YILMAZ BARBET, Mehmet Geylani ÖZOK
JOURNAL OF PEDIATRIC SURGERY, Journal Indexed in SCI Expanded, International, 1999, vol 34, pp 565-567
DOI: 10.1016/s0022-3468(99)90074-x
Summary
Background/Porpose: Early diagnosis of development of cholestasis is a current major problem for patients receiving total parenteral nutrition (TPN). Conventional tests for hepatic function such as serum transaminases and alkaline phosphatase do not often reflect simultaneously histopathologic changes of the liver. The aim of this study is to find out the relationships between conventional hepatic function tests, total serum bile acid concentrations (TSBA), and the histopathologic changes in the liver during TPN administration in rats.