Association between <i>vitamin D receptor</i> gene <i>FokI</i> polymorphism and mortality in patients with sepsis
Makaleler > Tam Makale · 2024
Yazarlar: Şükriye Miray KILINÇER BOZGÜL, Durdugul Ayyildiz Emecen, Funda KARBEK AKARCA, Devrim BOZKURT, Ozgur Aydin, Didem Koca, Özge CAN, Omer Vedat Unalp, Tahir Atik
MOLECULAR BIOLOGY REPORTS, SCI İndekslerine Giren Dergi, Uluslararası, Wos, 2024, cilt 51, ss 1-9
DOI: 10.1007/s11033-023-08971-8
Özet
Background Sepsis is life-threatening organ dysfunction as a result of the host's dysregulated immune response to infection. The vitamin D receptor (VDR) gene FokI polymorphism influences immune cell behavior. In the present study, we aimed to investigate the association between VDR FokI polymorphism and mortality in sepsis and non-sepsis patients in the intensive care unit (ICU).Methods and results This is a prospective observational study involving 96 sepsis and 96 non-sepsis patients admitted to the Ege University ICU. VDR FokI polymorphisms were investigated, as well as the relationship between the identified polymorphisms and mortality. In-hospital mortality was 27.1% in the sepsis group and 8.33% in the non-sepsis group (p = 0.001). The frequencies of VDR FokI TT, TC, and CC genotypes were 8 (8.33%), 48 (50.0%), and 40 (41.7%) in the sepsis group, and 11 (11.5%), 42 (43.8%), and 43 (44.8%) in the non-sepsis group, respectively (p = 0.612). In the sepsis group, the frequencies of Fokl TT, TC, and CC genotypes did not differ significantly between survivors and non-survivors. However, homozygous C allele carriers had lower overall mortality (p = 0.047).Methods and results This is a prospective observational study involving 96 sepsis and 96 non-sepsis patients admitted to the Ege University ICU. VDR FokI polymorphisms were investigated, as well as the relationship between the identified polymorphisms and mortality. In-hospital mortality was 27.1% in the sepsis group and 8.33% in the non-sepsis group (p = 0.001). The frequencies of VDR FokI TT, TC, and CC genotypes were 8 (8.33%), 48 (50.0%), and 40 (41.7%) in the sepsis group, and 11 (11.5%), 42 (43.8%), and 43 (44.8%) in the non-sepsis group, respectively (p = 0.612). In the sepsis group, the frequencies of Fokl TT, TC, and CC genotypes did not differ significantly between survivors and non-survivors. However, homozygous C allele carriers had lower overall mortality (p = 0.047).Conclusion The VDR FokI polymorphism, particularly the CC genotype, appears to be associated with lower mortality in ICU patients.