Synthesis, radiolabeling and biodistribution of a new opioid glucuronide derivative: ethyl-morphine glucuronide (em-glu)
Makaleler > Tam Makale · 2011
Yazarlar: H. Enginar, Perihan ÜNAK, Fazilet Zümrüt BİBER MÜFTÜLER, Fatma YURT, A. Yurt Kilcar, S. Yolcular, B. Seyitoglu, E. I. Medine, I. BULDUK
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2011, cilt 292, ss 667-673
DOI: 10.1007/s10967-011-1472-5
Özet
In current study, ethyl-morphine (em) was synthesized from the morphine and glucuronidated via enzymatic mechanism. The conjugated glucuronide ethylmorphine (em-glu) was radiolabeled with I-131 using iodogen method. The quality control studies of radiolabeled compound (I-131-em-glu) were done with Thin Layer Radio Chromatography to confirm the radiolabeling efficiency. Biodistribution studies of I-131 labeled em-glu were run on healthy male Albino Wistar rats. The distribution figures demonstrated that I-131-em-glu was eliminated through the small intestine, large intestine and accumulated in urinary bladder both receptor blocked and unblocked biodistribution studies. A greater uptake of the radiolabeled substance was observed in the m. pons, hypothalamus and mid brain than in the other branches of the rats' brains.