Olive leaf extract loaded silk fibroin/hyaluronic acid nanofiber webs for wound dressing applications
Articles > Article · 2016
Authors: G. Basal, G. D. Tetik, G. Kurkcu, Oğuz BAYRAKTAR, I. D. Gurhan, A. Atabey
Digest Journal of Nanomaterials and Biostructures, Journal Indexed in SCI Expanded, International, 2016, vol 11, pp 1113-1123
Summary
In this study a novel wound contact layer was developed by entrapping polyphenols obtained from olive leaf extract (OLE) inside the nanofibers made from the blend of hyaluronic acid and silk fibroin, produced by co axial electrospinning method. OLE has powerful antibacterial, anti fungal and antiviral properties and also known as a good antioxidant. The purpose of coaxial electrospinning was to achieve the controlled release of OLE by capturing it inside nanofibers. TEM images confirmed that OLE was successfully captured. Release profile of OLE loaded nanofibers indicated an initial burst release followed by a more gradual release. In vitro cytotoxicity tests indicated that the developed electrospun coaxial nanofibers were non-toxic.