Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report
Articles > Article ยท 2016
Authors: Hale Tuhan, Ayhan Abaci, Banu SARSIK KUMBARACI, Tulay Ozturk, Mustafa Olguner, Gonul Catli, Ahmet Anik, Nur Olgun, Ece Bober
Acta Clinica Belgica, Journal Indexed in SCI Expanded, International, WoS, 2016, vol 72, pp 254-258
DOI: 10.1080/17843286.2016.1215869
Summary
Intratubular large cell hyalinizing Sertoli cell neoplasia (ITLCHSCN) resulting from Sertoli cells of the testis are mainly reported in young adults and these are rarely seen in childhood. The most common presenting symptoms of the patients diagnosed with ITLCHSCN are gynecomastia, enlargement in the testicles, increase in growth velocity, and advanced bone age. Symptoms are basically resulting from increased aromatase enzyme activity in Sertoli cells. In this case report, an eight-and-a-half-year-old case presenting with complaint of bilateral gynecomastia since two years, showing no endocrine abnormality in laboratory during two years of follow-up, determined to have progression in bilateral gynecomastia, increase in testicular volumes, advanced bone age, increase in growth velocity in the clinical follow-up, and diagnosed with ITLCHSCN after testis biopsy was presented.