Treatment with milk thistle extract (Silybum marianum), ursodeoxycholic acid, or their combination attenuates cholestatic liver injury in rats: Role of the hepatic stem cells
Articles > Article · 2017
Authors: Nuray Alaca, DİLEK ÖZBEYLİ, SERAP USLU, Hasan Huseyin Sahin, Gurkan YIGITTURK, HIZIR KURTEL, Gülperi ÖKTEM, Berrak Caglayan Yegen
TURKISH JOURNAL OF GASTROENTEROLOGY, Journal Indexed in SCI Expanded, International, 2017, vol 28, pp 476-484
Summary
Background/Aims: Cholestasis, which results in hepatic cell death, fibrosis, cirrhosis, and eventually liver failure, is associated with oxidative stress. The aim of this study was to evaluate the effects of milk thistle (MT, Silybum marianum) and ursodeoxycholic acid (UDCA) or their combination on the activation of hepatic stem cells and on the severity of cholestasis liver injury in rats.