Telomerase inhibition regulates EMT mechanism in breast cancer stem cells
Makaleler > Tam Makale · 2020
Yazarlar: A Kusoglu, BAKİYE GÖKER BAĞCA, Neslihan Pınar ÖZATEŞ AY, Cumhur GÜNDÜZ, Çığır BİRAY AVCI
Gene, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2020, cilt 759, ss 145001-145001
DOI: 10.1016/j.gene.2020.145001
Özet
Backround: CSCs having the common features of high telomerase activity and high migration and invasion capabilities play a vital role as the initiators of metastasis. Small molecule BIBR1532 has been shown to target cancer cells by inhibiting telomerase. Recent studies have suggested that telomerase activity is associated with epithelial mesenchymal transition (EMT). EMT program, which causes epithelial cells to acquire a mesenchymal morphology, is known to play a significant role in cancer metastasis.