Mortality reduction by post-dilution online-haemodiafiltration: a cause-specific analysis
Articles > Article · 2016
Authors: Menso J. Nube, Sanne A. E. Peters, Peter J. Blankestijn, Bernard Canaud, Andrew Davenport, Muriel P. C. Grooteman, Gülay AŞCI, Francesco Locatelli, Francisco Maduell, Marion Morena, Ercan OK, Ferran Torres, Michiel L. Bots
NEPHROLOGY DIALYSIS TRANSPLANTATION, Journal Indexed in SCI Expanded, International, 2016, vol 32, pp gfw381-gfw381
DOI: 10.1093/ndt/gfw381
Summary
Background. From an individual participant data (IPD) meta-analysis from four randomized controlled trials comparing haemodialysis (HD) with post-dilution online-haemodiafiltration (ol-HDF), previously it appeared that HDF decreases all-cause mortality by 14% (95% confidence interval 25; 1) and fatal cardiovascular disease (CVD) by 23% (39; 3). Significant differences were not found for fatal infections and sudden death. So far, it is unclear, however, whether the reduced mortality risk of HDF is only due to a decrease in CVD events and if so, which CVD in particular is prevented, if compared with HD.