A distinct expression profile separates Turkish and Australian melanocytic naevi
Articles > Article · 2015
Authors: Carly Fox, Helmut SCHAİDER, Taner AKALIN, Meltem TÜRKMEN, Rick STURM, Duncan LAMBİE, Işıl TUNA, H. Peter Soyer, Fezal ÖZDEMİR, Brian Gabrielli
Histopathology, Journal Indexed in SCI Expanded, International, WoS, 2015, vol 69, pp 151-154
DOI: 10.1111/his.12906
Summary
Sir: Following the Clark model of melanoma progression, melanocytic naevi (MNs) are thought to be precursor lesions of melanomas. Although MNs have been described phenotypically and histologically,1-3 the biology and molecular features accompanying them remain puzzling. A major disadvantage in studying the biology of MNs is the complete absence of in-vitro and in-vivo models. Therefore, one approach to better define potential markers of MNs is the selection of candidate genes based on existing knowledge of genes known to be required for transformation into melanocytic tumours, and to probe for their tissue expression.