P1772 Assesment of total atrial conduction time in patients with atrioventricular nodal reentrant tachycardia with and without drug-induced type 1 Brugada pattern and control subjects
Bildiriler > Özet Bildiri
Yazarlar: U Kocabas, Can HASDEMİR
European Heart Journal - Cardiovascular Imaging, , , Uluslararası, Özet Bildiri, Wos, cilt 21
DOI: 10.1093/ehjci/jez319.1129
Özet
Abstract Background Most forms of atrioventricular nodal reentrant tachycardia (AVNRT) are created by reentry between 2 (or more) atrial connections to the AV node. There is a high prevalence of drug-induced type 1 Brugada ECG pattern (DI-Type1-BrP) among patients with AVNRT. Atrial vulnerability and structural remodeling that leads to reentrant circuits in AVNRT is largely unknown. PA-TDI interval assessed by tissue Doppler imaging is a useful technique to determine total atrial conduction time (TACT) which reflects atrial remodeling and arrhythmic substrate. Purpose In this prospective study, we aimed to assess TACT in patients with AVNRT with and without DI-Type1-BrP and control subjects. Methods Study population consisted of 62 consecutive patients (age 44 ± 12 years; 74% women) undergoing electrophysiological study and ablation for symptomatic, drug-resistant AVNRT and 42 age and sex matched control subjects. All patients and control subjects underwent ajmaline challenge test and tissue Doppler imaging. Results A DI-Type1-BrP was uncovered in 24 of 62 patients with AVNRT (38.7%). PA-TDI interval was longer in patients with AVNRT with or without DI-Type1-BrP compared to control subjects (124 ± 12 ms vs 119 ± 14 ms vs 105 ± 11 ms; P < 0.001, respectively). PA-TDI interval was similar in patients with AVNRT with or without DI-Type1-BrP (124 ± 12 ms vs 119 ± 14 ms; P = NS, respectively). PA-TDI interval was significantly correlated with P-wave duration on the surface ECG (r = 0.23; P = 0.02). Left atrial volume index and left atrial phasic functions were similar in patients with AVNRT with or without DI-Type1-BrP and control subjects. Conclusion TACT is prolonged in patients with AVNRT. Further studies are needed to determine the underlying factor(s) such as DI-Type1-BrP that leads to prolonged atrial conduction time.