The Relationship Between Trimethylamine-N-Oxide and Prevalent Cardiovascular Disease in a Multiethnic Population Living in Canada
Articles > Article ยท 2015
Authors: Andrew Mente, Kenneth Chalcraft, Handan AK, A. Darlene Davis, Eva Lonn, Ruby Miller, Murray A. Potter, Salim Yusuf, Sonia S. Anand, Matthew J. McQueen
CANADIAN JOURNAL OF CARDIOLOGY, Journal Indexed in SCI Expanded, International, 2015, vol 31, pp 1189-1194
DOI: 10.1016/j.cjca.2015.06.016
Summary
Background: Microflora-dependent trimethylamine-N-oxide (TMAO) formation, which results from intake of choline and L-carnitine-rich food, shows promise as a predictor of cardiovascular disease (CVD) risk, but these associations have not been examined in ethnically diverse populations. In a multiethnic population-based study of adults in Canada, we assessed the stability of TMAO and L-carnitine in stored serum samples and their association with intimal medial thickness, prevalent risk factors, and clinical events.