Drug–Drug Interactions in Patients with Brucellosis: A Retrospective Analysis
Makaleler > Tam Makale · 2026
Yazarlar: Bahar Çelebi, Meltem Tüğdür Ceylan, Fethiye Ferda YILMAZ, Meltem Taşbakan
Mediterranean Journal of Infection Microbes and Antimicrobials, Uluslararası, Scopus, 2026, cilt 15, ss 134-142
DOI: 10.4274/mjima.galenos.2026.26678
Özet
Introduction:The prolonged duration of drug treatment and the need for combination therapy in brucellosis increase the risk of drug-related problems.One of the most significant drug-related problems is drug-drug interactions.The aim of this study was to identify potential drug interactions that may occur during the treatment of patients with brucellosis, investigate their causes, and contribute to clinical practice. Materials and Methods:This retrospective study included 76 patients admitted to the Infectious Diseases and Clinical Microbiology Clinic of Ege University Faculty of Medicine Hospital between January 2016 and November 2022 because of brucellosis and/or its complications.Drug interactions among the antibiotics used by the patients and between these antibiotics and other medications were investigated.Lexicomp® and Micromedex® were used as interaction databases.The severity and number of drug interactions identified in each database were assessed.Additionally, gender, age, occupation, the presence of comorbidities, and comparisons of database results across other medication groups were evaluated.Data were analyzed using SPSS version 27.Ethics committee approval was obtained, and verbal informed consent was obtained from all patients.Results: Of the 76 patients included in the study, 49 were male, the mean age was 47.23 ± 14.16 years, and 53.95% had comorbidities.The mean number of drug interactions per patient was 4.88 ± 2.88 in LC and 2.63 ± 1.81 in MM.Significant associations were found between age, comorbidities, ciprofloxacin use, and the number of drug interactions in both databases (p < 0.05).When the interactions between antibiotics used for brucellosis and other medications were examined, the most common were decreased efficacy of doxycycline (97.30%), increased efficacy of gentamicin (54.17%), and decreased efficacy of rifampin (58.05%).The medications most commonly associated with decreased efficacy were statins, neurologic drugs, and antihypertensive agents (p = 0.001). Conclusion:In this study, we focused on drug interactions during antibiotic treatment.Long-term treatment and polypharmacy can lead to drug interactions.This can negatively affect treatment effectiveness and prolong the duration of therapy.