Fatal disseminated Acremonium strictum infection in a preterm newborn: a very rare cause of neonatal septicaemia
Articles > Article · 2003
Authors: Mehmet YALAZ, Süleyha HİLMİOĞLU POLAT, Dilek Yeşim METİN, Mete AKISU, Deniz NART, HASAN ÇETİN, CENGİZ ÖZTÜRK, ECMEL IŞIK, NİLGÜN KÜLTÜRSAY
JOURNAL OF MEDICAL MICROBIOLOGY, Journal Indexed in SCI Expanded, International, 2003, vol 52, pp 835-837
Summary
Species of the genus Acremonium (Cephalosporium) are opportunistic micro-organisms that are environmentally widespread saprophytes in soil and can, very rarely, be pathogenic in humans. Disseminated infection has been described in patients with immunodeficiency, but has previously been reported in only one neonate. A preterm infant with Acremonium strictum fungaemia is reported here. The patient was born at 27 weeks gestation and weighed 870 g at birth. She needed intensive respiratory management and became septic on day 11 of life. Blood and cerebrospinal fluid (CSF) cultures were positive for A. stricturn. The patient did not respond to therapy with amphotericin B plus fluconazole and died on day 25 of life. The autopsy showed foci due to A. stricturn in the brain, liver and heart.