Lacidipine has antiatherosclerotic effects independent of its actions on lipid metabolism and blood pressure
Makaleler > Tam Makale · 2010
Yazarlar: Günay YETİK ANACAK, Levent Ustunes, Özlem YILMAZ, Adviye ERGUL
Vascular Pharmacology, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2010, cilt 53, ss 193-199
DOI: 10.1016/j.vph.2010.08.003
Özet
The antiatherosclerotic effect of lacidipine has been attributed to its actions on cholesterol levels, lipid metabolism or oxidant stress in advanced disease. The purpose of the present experiments was to examine whether lacidipine is protective of intimal thickening and vascular dysfunction in early atherosclerosis in the absence of the hypertension and hypercholesterolemia. A second goal was to determine whether and to what extent MMP-9 and oxidant stress are involved in possible beneficial effects of lacidipine.