Ochronotic Arthropathy
Articles > Article ยท 2005
Authors: Arzu Celebi Kobak, Gonca Oder, ??enol Kobak, Mehmet Argin, Vedat Inal
JCR: Journal of Clinical Rheumatology, International, WoS, 2005, vol 11, pp 323-325
DOI: 10.1097/01.rhu.0000191157.25894.55
Summary
In Brief The deficiency of homogentisic acid oxidase, an enzyme that is mainly found in hepatocytes, is associated with alkaptonuria and ochronosis. We report a patient with clinical and radiologic findings of ochronotic arthropathy in whom alkaptonuria disappeared and the progressive course of the disease stopped after liver transplantation for hepatitis B-related cirrhosis. This patient with classic ochronosis had reversal of the alkaptonuria after liver transplantation, which appears to have replaced the missing homogenetic acid oxidase.