DRD4 genotyping may differentiate symptoms of attention-deficit/hyperactivity disorder and sluggish cognitive tempo
Makaleler > Tam Makale · 2020
Yazarlar: H Bolat, Eyüp Sabri ERCAN, G Ünsel-Bolat, HASAN AKIN TAHILLIOĞLU, KU Yazici, A Bacanli, Erhan PARILTAY, Duygu Döndü AYGÜNEŞ JAFARI, B Kosova, Semiha ÖZGÜL, LA Rohde, Haluk AKIN
BRAZILIAN JOURNAL OF PSYCHIATRY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2020, cilt 42, ss 630-637
DOI: 10.1590/1516-4446-2019-0630
Özet
Objective: Studies to reduce the heterogeneity of attention-deficit/hyperactivity disorder (ADHD) have increased interest in the concept of sluggish cognitive tempo (SCT). The aim of this study was to investigate if the prevalence of two variable-number tandem repeats (VNTRs) located within the 3'-untranslated region of the DAT1 gene and in exon 3 of the dopamine D4 receptor (DRD4) gene differ among four groups (31 subjects with SCT but no ADHD, 146 individuals with ADHD but no SCT, 67 subjects with SCT + ADHD, and 92 healthy controls).