Stevens-Johnson Syndrome associated with methotrexate treatment for acutelymphoblastic leukemia: a case report
Articles > Article ยท 2018
Authors: Burcu Akinci, Zuhal O. Sivis, Akkiz Sahin, Deniz YILMAZ KARAPINAR, Can BALKAN, Ramazan Kaan KAVAKLI, Yesim Aydinok
Archivos Argentinos de Pediatria, Journal Indexed in SCI Expanded, International, WoS, 2018, vol 116, pp e459-e462
DOI: 10.5546/aap.2018.eng.e459
Summary
Toxic epidermal necrolysis and Stevens-Johnson syndrome are rare mucocutaneous diseases which are associated with a prolonged course and potentially lethal outcome. They are mostly drug induced and mortality rates are very high. Although mostly skin is involved, multiple organ systems such as cardiovascular, pulmonary, gastrointestinal, and urinary systems may be affected. Here, we report a case of Stevens- Johnson Syndrome associated with methotrexate treatment who developed acute cardiac failure and gastrointestinal hemorrhage beside skin findings. He had been treated with intravenous immunglobulin and methylprednisolone succesfully and continued chemotherapy with methotrexate treatment again.