Acrylamide-encapsulated glucose oxidase inhibits breast cancer cell viability
Articles > Article · 2020
Authors: Trendelina Rrustemi, Oyku Gonul Geyik, Ali Burak Ozkaya, Taylan Kurtuluş ÖZTÜRK, Zeynep Yuce, Ali KILINÇ
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, Journal Indexed in SCI Expanded, International, 2020, vol 45, pp 811-816
Summary
Objectives: Cancer cells modulate metabolic pathways to ensure continuity of energy, macromolecules and redoxhomeostasis. Although these vulnerabilities are often targeted individually, targeting all with an enzyme may prove a novel approach. However, therapeutic enzymes are prone to proteolytic degradation and neutralizing antibodies leading to a reduced half-life and effectiveness. We hypothesized that glucose oxidase (GOX) enzyme that catalyzes oxidation of glucose and production of hydrogen peroxide, may hit all these targets by depleting glucose; crippling anabolic pathways and producing reactive oxygen species (ROS); unbalancing redox homeostasis.