Thyroidal angiogenesis in zebrafish ( Danio rerio ) exposed to high perchlorate concentration
Makaleler > Tam Makale · 2009
Yazarlar: Sema İşisağ Üçüncü, Oeduel Karayazi, Aydın İşisağ
AFRICAN JOURNAL OF BIOTECHNOLOGY, Uluslararası, Wos, 2009, cilt 8, ss 1729-1733
Özet
As a well known environmental contaminant, perchlorate inhibits thyroidal iodide uptake and reduces thyroid hormone levels. In zebrafish (Danio rerio) exposed to high concentrations of sodium perchlorate (200, 350 and 500 mg/L) for 10 days, remarkable angiogenesis was identified, not only histopathologically but also statistically by counting of the small, medium and large sized (grades 1 to 3) vessels per unit area. Angiogenic response is concluded as the most sensitive parameter for rating of high concentrations of perchlorate exposure.