Enteral resveratrol supplementation attenuates intestinal epithelial inducible nitric oxide synthase activity and mucosal damage in experimental necrotizing enterocolitis
Makaleler > Tam Makale · 2007
Yazarlar: Mustafa Orkan ERGÜN, Gueliz ERGUEN, Guelperi OEKTEM, Nur SELVİ GÜNEL, Hakan DOGAN, Muege TUNCYUEREK, Güray SAYDAM, Ata ERDENER
Journal of Pediatric Surgery, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2007, cilt 42, ss 1687-1694
DOI: 10.1016/j.jpedsurg.2007.05.024
Özet
Background/Purpose: The release of various enzymes including inducible nitric oxide synthase (iNOS) leads to enterocyte apoptosis through free nitrogen radicals, which in turn leads to impaired mucosal barrier and bacterial translocation with resultant sepsis in necrotizing enterocolitis (NEC). Resveratrol, a polyphenol compound from phytoalexins with antioxidant and scavenger properties, also play a critical role in modulating key enzymes in cell cycle including iNOS. We therefore hypothesized that resveratrol would prevent mucosal damage in experimental NEC in rats.