A rare complication of leukostasis with AML M4 patient: Microcirculatory dysfunction of upper extremities
Articles > Article · 2023
Authors: İrem Ersayoğlu, Pınar YAZICI ÖZKAYA, Hamdi Metin, Hamiyet Hekimci, Kazım Zararcı, Deniz Yılmaz Karapınar, Bülent Karapınar
Transfusion and Apheresis Science, Journal Indexed in SCI Expanded, International, WoS, 2023, vol 62, pp 103717-103717
DOI: 10.1016/j.transci.2023.103717
Summary
Background: In children with acute myeloid leukemia, the incidence of hyperleukocytosis is 5–33%. Patients with AML and hyperleukocytosis have a higher early mortality rate than patients with nonhyperleukocytic AML because of the increased risk of severe pulmonary and neurologic complications. Leukapheresis provides rapid cytoreduction and reduces early mortality rates. Case presentation: In this report, we present a case with microcirculatory failure of upper extremities as a rare symptom of hyperleukocytic AML M4 at initial presentation. Conclusions: Early diagnosis and treatment of patients with AML admitted to emergency services with these symptoms is too important to prevent from loss of extremities. Most of the complications of hyperleukocytosis can be reversible with early treatment.