Molecular imprinted magnetic nanoparticles for controlled delivery of mitomycin C
Articles > Article · 2013
Authors: Deniz Türkmen, Nilay Bereli, M. Emin Çorman, Huma Shaikh, Sinan Akgöl, Adil Denizli
Artificial Cells, Nanomedicine, and Biotechnology, International, Scopus, 2013, vol 42, pp 316-322
DOI: 10.3109/21691401.2013.823094
Summary
Controlled drug delivery system is a technique which has considerable recent potential in the fields of pharmacy and medicine. Mitomycin C is commonly used drug in the treatment of superficial bladder and breast cancers. In the present study, mitomycin C-imprinted magnetic poly(hydroxyethyl methacrylate)-based nanoparticles (MIMNs) were prepared using surfactant free emulsion polymerization for controlled delivery of mitomycin C. The MIMNs were characterized by fourier transform infrared spectroscopy, scanning electron microscopy, atomic force microscopy, electron spin resonance, and elemental analysis. The average particle diameter of MIMNs was about 200 nm.